44 research outputs found
Recognizing Interactions Between People from Video Sequences
his research study proposes a new approach to group activ- ity recognition which is fully automatic. The approach adopted is hierar- chical, starting with tracking and modelling local movement leading to the segmentation of moving regions. Interactions between moving regions are modelled using Kullback-Leibler (KL) divergence. Then the statistics of such movement interactions or as relative positions of moving regions is represented using kernel density estimation (KDE). The dynamics of such movement interactions and relative locations is modelled as well in a development of the approach. Eventually, the KDE representations are subsampled and considered as inputs of a support vector machines (SVM) classifier. The proposed approach does not require any interven- tion by an operato
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Universal DNA methylation age across mammalian tissues.
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals